Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 3/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370656 | 1.00 | SLC1A1 (0.50) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 | |
| SCHEMBL30768315 | 0.81 | ALDH1A1 (0.49) | KMT2AMEN1PPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL4878777 | 0.81 | GAA (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2269230 | 0.78 | SLC1A1 (0.53) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 | |
| SCHEMBL11635275 | 0.77 | CNR2 (0.54) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 | |
| SCHEMBL28875926 | 0.77 | FOLH1 (0.58) | SLC1A1PPARGFOLH1 | |
| SCHEMBL28329699 | 0.76 | SLC1A1 (0.50) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 | |
| SCHEMBL1816769 | 0.74 | TDP1 (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1231110 | 0.74 | SLC1A1 (0.59) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 | |
| SCHEMBL8553178 | 0.74 | SLC1A1 (0.59) | SLC1A1SLC1A3SLC1A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |