Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678097 | 0.85 | ALDH1A1 (0.44) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6681993 | 0.84 | ALDH1A1 (0.43) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6680298 | 0.84 | CA1 (0.37) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6677707 | 0.83 | MAPT (0.42) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6683256 | 0.83 | ALDH1A1 (0.43) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6678153 | 0.80 | ALDH1A1 (0.40) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5375903 | 0.80 | CA1 (0.55) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3486328 | 0.78 | CA1 (0.51) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL11794387 | 0.78 | CA1 (0.54) | CA1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13254537 | 0.78 | CA1 (0.51) | CA1HPGDMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39530-E1 | 3-amino-3-arylpropan-1-ol-compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-03-27 | — | — | US | disclosed |
| EP-1289514-B1 | USE OF SUBSTITUTED 1-AMINO-5-PHENYLPENTANE-3-OL AND/OR 1-AMINO-6-PHENYLHEXANE-3-OL COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2004-11-03 | — | — | EP | disclosed |
| EP-1043306-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and use | GRUENENTHAL GMBH (DE) | 2004-03-31 | — | — | EP | disclosed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| US-6288278-B1 | BENZENE DERIVED AMINO ALCOHOLS AS DRUGS | GRUENENTHAL GMBH (DE) | 2001-09-11 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| EP-1043306-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |