Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429168 | 1.00 | PAK1 (0.68) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL8411239 | 0.88 | MAPK1 (0.70) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL8411247 | 0.88 | MAPK1 (0.70) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL5373331 | 0.83 | TLK2 (0.67) | NTRK1PDGFRBKDRPDGFRAFLT3 | |
| SCHEMBL8415627 | 0.81 | PAK1 (1.00) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL8415630 | 0.81 | PAK1 (1.00) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL5357950 | 0.78 | PAK1 (0.46) | PAK1MAPK1PDGFRBKDRPDGFRA | |
| SCHEMBL5369667 | 0.78 | HDAC3 (0.65) | PAK1MAPK1NTRK1PDGFRBKDR | |
| SCHEMBL5362266 | 0.78 | HDAC3 (0.46) | PAK1PDGFRBKDRPDGFRATLK2 | |
| SCHEMBL8585109 | 0.78 | PAK1 (0.66) | PAK1NTRK1PDGFRBKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752985-B1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-08-04 | — | — | EP | claimed |