Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10546745 | 0.86 | CYSLTR2 (0.50) | CYSLTR2CYSLTR1KMT2ANPC1RAB9A | |
| SCHEMBL7456253 | 0.84 | CYSLTR1 (0.49) | CYSLTR2CYSLTR1MEN1KMT2ANPC1 | |
| SCHEMBL7455761 | 0.84 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1NPC1RAB9ACYP3A4 | |
| Hydrogen Sulfide SCHEMBL9818421 | 0.83 | CYSLTR1 (0.48) | CYSLTR2CYSLTR1MEN1KMT2ANPC1 | |
| SCHEMBL9719792 | 0.79 | CYP1A2 (0.44) | CYSLTR2CYSLTR1KMT2ACYP3A4KDM4E | |
| SCHEMBL14021859 | 0.78 | CYSLTR1 (0.58) | CYSLTR2CYSLTR1MEN1KMT2ANPC1 | |
| SCHEMBL2877991 | 0.75 | CYSLTR1 (0.52) | CYSLTR2CYSLTR1KDM4EPDE10ANCF1 | |
| SCHEMBL3389504 | 0.75 | KDM1A (0.53) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL7460680 | 0.74 | CYP1A2 (0.43) | CYSLTR2CYSLTR1CYP3A4KDM4ESMN1; SMN2 | |
| SCHEMBL7714637 | 0.74 | CYSLTR1 (0.43) | CYSLTR2CYSLTR1CYP3A4KDM4EPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | CYSLTR2 3459/4885CYSLTR1 3338/4885MEN1 4855/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | CYSLTR2 3464/4885CYSLTR1 3318/4885MEN1 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.