SCHEMBL9719792

SCHEMBL9719792

Nc1c(Cl)cc(SCc2ccc3ccccc3n2)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
CYP2E1 P05181 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C8 P10632 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2B6 P20813 1/20 0.44
CYP2C19 P33261 1/20 0.44
CYSLTR2 Q9NS75 2/20 0.41
CYSLTR1 Q9Y271 2/20 0.41
PDE10A Q9Y233 2/20 0.40
NCF1 P14598 1/20 0.39
NOS2 P35228 1/20 0.39
BACE1 P56817 1/20 0.39
HTR3A P46098 1/20 0.38
POLB P06746 1/20 0.37
CTDSP1 Q9GZU7 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5373500 0.79 CYSLTR2 (0.49) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL10546745 0.78 CYSLTR2 (0.50) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL6637309 0.75 RAB9A (0.47) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL9719840 0.75 CYP1A2 (0.48) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL7456253 0.73 CYSLTR1 (0.49) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL7455761 0.73 CYSLTR2 (0.49) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL7460680 0.72 CYP1A2 (0.43) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL7714637 0.72 CYSLTR1 (0.43) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
Hydrogen Sulfide SCHEMBL9818421 0.72 CYSLTR1 (0.48) CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6
SCHEMBL2877991 0.70 CYSLTR1 (0.52) CYP1A2CYSLTR2CYSLTR1PDE10ANCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5157039-A Lipoxygenase inhibitors LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1992-10-20 US disclosed
US-5109009-A QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1992-04-28 US disclosed
US-4826987-A Pyridyl and quinoline derivatives LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1989-05-02 US disclosed