Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675165 | 1.00 | KDM4E (0.41) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2674752 | 0.87 | KDM4E (0.57) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2675462 | 0.84 | ALK (0.39) | KCNH2ALK | |
| SCHEMBL605159 | 0.82 | KDM4E (0.41) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2675766 | 0.79 | KCNH2 (0.39) | KCNH2ALK | |
| SCHEMBL537747 | 0.78 | IKBKB (0.33) | ALK | |
| SCHEMBL2676459 | 0.74 | ALK (0.33) | KDM4EALDH1A1HPGDHSD17B10ALK | |
| SCHEMBL2676884 | 0.73 | KDM4E (0.41) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2880218 | 0.73 | KDM4E (0.41) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL537639 | 0.72 | IKBKB (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414368-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115184-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | WO | claimed |