Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.35 |
| ▸ | RELA | Q04206 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | STK25 | O00506 | 1/20 | 0.34 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | MUSK | O15146 | 1/20 | 0.34 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250243 | 0.87 | HTR1B (0.71) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5309051 | 0.85 | HTR1B (0.58) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5443260 | 0.85 | HTR1B (0.56) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5308377 | 0.85 | HTR1B (0.57) | HTR1BKCNH2PARP1NFKB1NFKB2 | |
| SCHEMBL5308451 | 0.84 | HTR1B (0.78) | HTR1BKCNH2HTR1AHTR1DHTR2A | |
| SCHEMBL14529770 | 0.83 | HTR1B (0.66) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5308374 | 0.83 | HTR1B (0.59) | HTR1BKCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4247598 | 0.82 | HTR1B (0.65) | HTR1BKCNH2HTR1AHTR1DHTR2A | |
| SCHEMBL5308402 | 0.82 | HTR1B (0.57) | HTR1BKCNH2NFKB1NFKB2RELA | |
| SCHEMBL5309254 | 0.82 | HTR1B (0.60) | HTR1BKCNH2NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |