Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368559 | 0.90 | MAPK14 (0.47) | MAPK14PTGS2PTGS1TRPM8TRPA1 | |
| SCHEMBL5373901 | 0.85 | PTGS2 (0.59) | MAPK14PTGS2PTGS1 | |
| SCHEMBL6594766 | 0.84 | MAPK14 (0.49) | MAPK14PTGS2PTGS1TRPA1MAT2A | |
| SCHEMBL5366953 | 0.83 | MAPK14 (0.54) | MAPK14PTGS2PTGS1 | |
| SCHEMBL5377150 | 0.83 | MAPK14 (0.48) | MAPK14PTGS2PTGS1TRPA1MAT2A | |
| SCHEMBL5368804 | 0.82 | MAPK14 (0.47) | MAPK14PTGS2PTGS1 | |
| SCHEMBL5364997 | 0.81 | MAPK14 (0.46) | MAPK14PTGS2PTGS1TRPA1MAT2A | |
| SCHEMBL5365209 | 0.81 | MAPK14 (0.46) | MAPK14PTGS2PTGS1TRPA1MAT2A | |
| SCHEMBL5370333 | 0.80 | MAPK14 (0.45) | MAPK14PTGS2PTGS1TRPA1 | |
| SCHEMBL5365258 | 0.80 | MAPK14 (0.43) | MAPK14PTGS2PTGS1TRPA1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223772-B1 | Pyrazolopyridine derivatives as selective cox-2 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-29 | — | — | US | claimed |
| EP-1127058-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2004-09-01 | — | — | EP | claimed |
| US-7223772-B1 | Pyrazolopyridine derivatives as selective cox-2 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |