SCHEMBL5374396

SCHEMBL5374396

Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCCNC(=O)Oc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FAAH O00519 11/20 1.00
CNR1 P21554 1/20 0.77
CNR2 P34972 1/20 0.77
PLA2G4A P47712 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4261674 1.00 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL4410275 1.00 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL4273039 0.94 FAAH (0.89) FAAHCNR1CNR2PLA2G4A
SCHEMBL4267014 0.94 FAAH (0.89) FAAHCNR1CNR2PLA2G4A
SCHEMBL4551159 0.94 FAAH (0.89) FAAHCNR1CNR2PLA2G4A
SCHEMBL4267650 0.93 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4551680 0.93 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4265722 0.93 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4260370 0.93 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4260237 0.93 FAAH (0.87) FAAHCNR1CNR2PLA2G4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39634-E1 Bisarylimidazoly fatty acid amide hydrolase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-15 US claimed
US-RE39634-E1 Bisarylimidazoly fatty acid amide hydrolase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-15 US disclosed
US-RE39634-E1 Bisarylimidazoly fatty acid amide hydrolase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-15 US disclosed
US-RE39634-E1 Bisarylimidazoly fatty acid amide hydrolase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-15 US disclosed