SCHEMBL5375004

SCHEMBL5375004

NC[C@H]1CN(c2cc(F)c(C3[C@H]4CSC[C@@H]34)c(F)c2)C(=O)O1

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F10 P00742 2/20 0.48
CALML3 P27482 6/20 0.42
MAOA P21397 2/20 0.41
MAOB P27338 1/20 0.41
GRM2 Q14416 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14370660 1.00 F10 (0.48) F10CALML3MAOAMAOBGRM2
SCHEMBL13939900 0.84 F10 (0.46) F10CALML3MAOAMAOB
SCHEMBL18396742 0.82 MAOA (0.42) F10CALML3MAOAMAOBGRM2
SCHEMBL3368973 0.81 F10 (0.49) F10CALML3MAOAMAOBGRM2
SCHEMBL12956131 0.81 F10 (0.49) F10CALML3MAOAMAOBGRM2
SCHEMBL3368977 0.81 F10 (0.49) F10CALML3MAOAMAOBGRM2
SCHEMBL5394054 0.81 MAOA (0.52) F10CALML3MAOAMAOB
SCHEMBL14197133 0.80 MAOA (0.64) F10CALML3MAOAMAOB
SCHEMBL4881542 0.80 MAOA (0.64) F10CALML3MAOAMAOB
SCHEMBL4879072 0.80 MAOA (0.60) F10CALML3MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 US disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 F10 3090/4885CALML3 3870/4885MAOA 1957/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.