SCHEMBL5375013

SCHEMBL5375013

CCC(=O)NC[C@H]1CN(c2ccc(C3[C@H]4CN(Cc5ccc(OC)cc5)C[C@@H]34)c(F)c2)C(=O)O1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.46
MAOA P21397 4/20 0.45
MAOB P27338 3/20 0.45
LMNA P02545 1/20 0.45
PTGS1 P23219 1/20 0.45
CALML3 P27482 1/20 0.45
SDHA P31040 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14370578 1.00 F10 (0.46) F10MAOAMAOBLMNAPTGS1
SCHEMBL14224728 0.92 MAOA (0.54) F10MAOAMAOBLMNAPTGS1
SCHEMBL4881816 0.92 MAOA (0.54) F10MAOAMAOBLMNAPTGS1
SCHEMBL5374997 0.91 F10 (0.44) F10MAOAMAOBLMNAPTGS1
SCHEMBL14370645 0.91 F10 (0.44) F10MAOAMAOBLMNAPTGS1
SCHEMBL14197115 0.88 F10 (0.46) F10MAOAMAOBLMNAPTGS1
SCHEMBL4880673 0.84 MAOA (0.51) F10MAOAMAOBLMNAPTGS1
SCHEMBL4883356 0.84 MAOB (0.55) F10MAOAMAOBLMNAPTGS1
SCHEMBL5371772 0.83 F10 (0.49) F10MAOAMAOBLMNAPTGS1
SCHEMBL5374145 0.82 MAOA (0.56) F10MAOAMAOBLMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 US disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 F10 3090/4885MAOA 1957/4885MAOB 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.