SCHEMBL5375216

SCHEMBL5375216

CC(C)(C)N(C[C@@H]1CN(c2ccc(C3[C@H]4CN(C(N)=O)C[C@@H]34)c(F)c2)C(=O)O1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.44
MAOA P21397 7/20 0.42
CALML3 P27482 7/20 0.39
LMNA P02545 1/20 0.39
PTGS1 P23219 1/20 0.39
SDHA P31040 1/20 0.39
F10 P00742 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5370429 0.89 MAOB (0.43) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5382920 0.88 MAOB (0.44) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5375020 0.85 GRM2 (0.41) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5374406 0.84 CALML3 (0.41) MAOBMAOACALML3LMNAPTGS1
SCHEMBL4884096 0.81 F10 (0.51) MAOBMAOACALML3LMNAPTGS1
SCHEMBL4881204 0.80 MAOA (0.61) MAOBMAOACALML3LMNAPTGS1
SCHEMBL14197126 0.80 MAOA (0.61) MAOBMAOACALML3LMNAPTGS1
SCHEMBL4884103 0.80 MAOA (0.46) MAOBMAOACALML3LMNAPTGS1
SCHEMBL14197129 0.79 MAOA (0.49) MAOBMAOACALML3LMNAPTGS1
SCHEMBL5369851 0.79 F10 (0.51) MAOBMAOACALML3LMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 US disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 MAOB 1797/4885MAOA 1957/4885CALML3 3870/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.