Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | FYN | P06241 | 5/20 | 0.39 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239007 | 0.78 | KDR (0.48) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL2237544 | 0.76 | KDR (0.60) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL1703608 | 0.74 | KDR (0.50) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL2236724 | 0.69 | KDR (0.58) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL2239754 | 0.68 | KDR (0.62) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL2235613 | 0.68 | KDR (0.49) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL2239715 | 0.68 | KDR (0.51) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL12346395 | 0.67 | KDR (0.63) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL5418769 | 0.67 | KDR (0.48) | KDRFYNKITFLT3CSF1R | |
| SCHEMBL14294640 | 0.67 | KDR (0.65) | KDRFYNKITFLT3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845978-A1 | SUBSTITUTED PYRAZOLO-PYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-24 | — | — | EP | claimed |
| WO-2006077319-A1 | SUBSTITUTED PYRAZOLO-PYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-07-27 | — | — | WO | claimed |