Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.50 |
| ▸ | KIT | P10721 | 7/20 | 0.50 |
| ▸ | FLT3 | P36888 | 7/20 | 0.50 |
| ▸ | FYN | P06241 | 5/20 | 0.50 |
| ▸ | CSF1R | P07333 | 5/20 | 0.50 |
| ▸ | FLT1 | P17948 | 5/20 | 0.50 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
| ▸ | BLK | P51451 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784983 | 0.85 | KDR (0.62) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27636405 | 0.83 | KDR (0.47) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27657341 | 0.83 | KDR (0.54) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27636403 | 0.83 | KDR (0.48) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27657323 | 0.83 | KDR (0.45) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL5418769 | 0.82 | KDR (0.48) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27657351 | 0.79 | KDR (0.61) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL1702977 | 0.79 | KDR (0.75) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27636366 | 0.79 | KDR (0.44) | KDRKITFLT3FYNCSF1R | |
| SCHEMBL27636396 | 0.79 | AURKA (0.47) | KDRKITFLT3FYNCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807424-B1 | NOVEL KINASE INHIBITORS | ABBOTT LAB (US) | 2012-04-18 | — | — | EP | claimed |