Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363857 | 0.90 | ADORA2A (0.51) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL5363853 | 0.90 | ADORA2A (0.51) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL6179672 | 0.89 | ALDH1A1 (0.57) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL14337671 | 0.85 | ALDH1A1 (0.57) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL5365518 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL5372692 | 0.84 | ADORA2A (0.70) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5372695 | 0.84 | ADORA2A (0.70) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL6181351 | 0.83 | ADORA2A (0.53) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL5133408 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTTSHRHSD17B10ADORA2A | |
| SCHEMBL24349660 | 0.80 | ADORA2A (0.67) | ALDH1A1MAPTTSHRHSD17B10ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304058-B2 | For therapy of Alzheimer's disease, depression | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | claimed |