Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.41 |
| ▸ | CTSB | P07858 | 12/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377921 | 0.92 | BACE1 (0.40) | BACE1CTSBCTSDBACE2 | |
| SCHEMBL5383729 | 0.90 | BACE1 (0.54) | BACE1CTSBCTSD | |
| SCHEMBL5388135 | 0.87 | BACE1 (0.41) | BACE1CTSBCTSD | |
| SCHEMBL5375820 | 0.80 | BACE1 (0.49) | BACE1CTSBCTSDBACE2 | |
| SCHEMBL5378082 | 0.80 | BACE1 (0.44) | BACE1CTSB | |
| Trifluoroacetic Acid SCHEMBL5131116 | 0.78 | BACE1 (0.53) | BACE1CTSBCTSD | |
| SCHEMBL3352491 | 0.78 | BACE1 (0.63) | BACE1CTSBCTSD | |
| SCHEMBL3351920 | 0.72 | BACE1 (0.47) | BACE1CTSBCTSD | |
| SCHEMBL3350542 | 0.72 | BACE1 (0.47) | BACE1CTSBCTSD | |
| Trifluoroacetic Acid SCHEMBL5381946 | 0.71 | BACE1 (0.58) | BACE1CTSBCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171881-A1 | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | PHARMACIA & UPJOHN COMPANY | 2004-09-02 | — | — | US | claimed |
| US-7176242-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171881-A1 | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | BACE1, BACE2, PSEN1 | BACE1 1/4885CTSB 317/4885CTSD 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.