Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.90 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381276 | 1.00 | GSK3B (0.90) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5400097 | 1.00 | GSK3B (0.90) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5381263 | 0.99 | GSK3B (0.92) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5386254 | 0.94 | GSK3B (1.00) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5380514 | 0.89 | GSK3B (0.84) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL3854866 | 0.83 | SMN1; SMN2 (0.74) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5382475 | 0.82 | GSK3B (0.77) | GSK3BGPR84SMN1; SMN2XDH | |
| SCHEMBL5387930 | 0.80 | GSK3B (1.00) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5390457 | 0.79 | GSK3B (0.72) | GSK3BGPR84SMN1; SMN2XDHCDC7 | |
| SCHEMBL5381271 | 0.78 | GSK3B (0.56) | GSK3BGPR84CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |