Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981250 | 0.89 | HDAC6 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13002093 | 0.88 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4985615 | 0.85 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4846237 | 0.81 | RAB9A (0.67) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4981258 | 0.81 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1761771 | 0.80 | HDAC6 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1820638 | 0.79 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1822209 | 0.79 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1821539 | 0.79 | PDE10A (0.67) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4981717 | 0.79 | HDAC6 (0.57) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205312-B2 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-17 | — | — | US | disclosed |
| US-20050113378-A1 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | JANSSEN PHARMACEUTICA, N.V. | 2005-05-26 | — | — | US | disclosed |
| US-6833375-B2 | As inhibitors of the retinoic acid-metabolism, as drugs | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-12-21 | — | — | US | disclosed |
| US-20030176419-A1 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | VENET MARC GASTON (FR) | 2003-09-18 | — | — | US | disclosed |
| EP-0907650-B1 | N- 4-(HETEROARYLMETHYL)PHENYL]-HETEROARYLAMINES | JANSSEN PHARMACEUTICA NV (BE) | 2002-12-04 | — | — | EP | disclosed |
| US-6486187-B1 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-11-26 | — | — | US | disclosed |
| US-6124330-A | A RETINOIC MIMETIC COMPOUND FOR TREATING A WARM-BLOODED ANIMAL SUFFERING FROM A DISEASE BY AN ABNORMAL PROLIFERATION AND/OR ABNORMAL DIFFERENTIATION OF NORMAL, PRENEOPLASTIC OR NEOPLASTIC CELLS | JANSSEN-CILAG S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113378-A1 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | CYP2S1, CYP2D6, CYP2C19 | NPC1 520/4885RAB9A 2326/4885SMN1; SMN2 4222/4885 |
| US-20030176419-A1 | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines | CYP8B1, CYP2S1, CYP2B6 | NPC1 298/4885RAB9A 2697/4885SMN1; SMN2 3757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.