Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.50 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10633653 | 0.98 | MEN1 (0.58) | MEN1KMT2ARAB9AASIC3TRPV3 | |
| SCHEMBL29595186 | 0.84 | CCR1 (0.40) | MEN1KMT2ARAB9ATRPV3ALDH1A1 | |
| SCHEMBL9356103 | 0.84 | CCR1 (0.40) | MEN1KMT2ARAB9ATRPV3ALDH1A1 | |
| SCHEMBL4592241 | 0.84 | GFER (0.47) | MEN1KMT2ARAB9AALDH1A1HPGD | |
| SCHEMBL5114437 | 0.83 | MEN1 (0.65) | MEN1KMT2ARAB9AASIC3TRPV3 | |
| SCHEMBL5645917 | 0.83 | MEN1 (0.65) | MEN1KMT2ARAB9AASIC3TRPV3 | |
| SCHEMBL8989216 | 0.82 | MEN1 (0.43) | MEN1KMT2ARAB9ATRPV3ALDH1A1 | |
| SCHEMBL6484177 | 0.82 | SCN9A (0.43) | MEN1KMT2ARAB9ATRPV3ALDH1A1 | |
| SCHEMBL4592022 | 0.81 | CNR2 (0.46) | — | |
| SCHEMBL4435179 | 0.79 | MEN1 (0.60) | MEN1KMT2ARAB9AASIC3TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014003483-A1 | FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES | HANMI PHARM. CO., LTD. (KR) | 2014-01-03 | — | — | WO | disclosed |
| US-RE41425-E1 | used for the treatment of affective disorders or diseases of the central nervous system caused by disturbances in either the dopaminergic or serotinergic systems, such as schizophrenia | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2010-07-06 | — | — | US | disclosed |
| US-RE41425-E1 | used for the treatment of affective disorders or diseases of the central nervous system caused by disturbances in either the dopaminergic or serotinergic systems, such as schizophrenia | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2010-07-06 | — | — | US | disclosed |
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| CN-1260227-C | 5-membered ring heterocyclic compounds with nitrogen | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-06-21 | — | — | CN | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| CN-1413207-A | 5-membered ring heterocyclic compounds with nitrogen | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-04-23 | — | — | CN | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |
| EP-0535923-A1 | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0518426-A1 | Thiopyrano (2,3,4-c,d) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-12-16 | — | — | EP | disclosed |
| US-5103014-A | Antiinflammatory or/and antiallergic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| US-4942236-A | ANTIASTHMATICS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-07-17 | — | — | US | disclosed |
| US-4895953-A | 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-23 | — | — | US | disclosed |
| US-4826990-A | LIPOXYGENASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0310370-A1 | 2-aryl substituted heterocyclic compounds as antiallgeric and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |
| EP-0146370-B1 | IMIDAZOQUINOLINES CONTAINING OTHER HETEROCYCLIC GROUPS | JOHN WYETH & BROTHER LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |
| US-4703044-A | Imidazoquinolines containing other heterocyclic groups, useful as anti-ulcer or anti-secretory agents | JOHN WYETH & BROTHER LIMITED (GB) | 1987-10-27 | — | — | US | disclosed |
| EP-0146370-A2 | Imidazoquinolines containing other heterocyclic groups | JOHN WYETH & BROTHER LIMITED (GB) | 1985-06-26 | — | — | EP | disclosed |