SCHEMBL5377044

SCHEMBL5377044

CCN1CC(=O)N(CC(Cl)Cl)C1=O

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 6/20 0.37
F2 P00734 1/20 0.33
ELANE P08246 1/20 0.33
CTSG P08311 1/20 0.33
CTRC Q99895 1/20 0.33
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
PRMT5 O14744 1/20 0.31
WDR77 Q9BQA1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14582995 0.83 PIK3CD (0.40) HDAC6F2ELANECTSGCTRC
SCHEMBL14355314 0.81 HDAC6 (0.34) HDAC6F2ELANECTSGCTRC
SCHEMBL417344 0.80 F2 (0.48) HDAC6F2ELANECTSGCTRC
SCHEMBL7745388 0.79 F2 (0.37) HDAC6F2ELANECTSGCTRC
SCHEMBL5826351 0.77 HDAC6 (0.45) HDAC6
SCHEMBL10963708 0.75 F2 (0.37) HDAC6F2ELANECTSGCTRC
SCHEMBL632190 0.75 F2 (0.37) HDAC6F2ELANECTSGCTRC
SCHEMBL630916 0.73 ENPP2 (0.39) F2ELANECTSGCTRC
SCHEMBL24131214 0.72 HDAC6 (0.38) HDAC6F2ELANECTSGCTRC
SCHEMBL10965861 0.72 HDAC6 (0.35) HDAC6F2ELANECTSGCTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1789099-A1 IMPROVED DISPENSING DEVICE Reckitt Benckiser Inc. (US) 2007-05-30 EP disclosed
WO-2006013322-A1 IMPROVED DISPENSING DEVICE RECKITT BENCKISER INC (US) 2006-02-09 WO disclosed