SCHEMBL5377178

SCHEMBL5377178

C1=CC2CC1CC2Cc1ccc(CC2CC3C=CC2C3)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 12/20 0.47
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
HTT P42858 2/20 0.47
TSHR P16473 1/20 0.44
TDP1 Q9NUW8 3/20 0.41
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
ATM Q13315 1/20 0.35
PKM P14618 2/20 0.35
POLB P06746 1/20 0.33
ALOX15 P16050 1/20 0.33
IDO1 P14902 1/20 0.32
TDO2 P48775 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15367747 0.91 KDM4E (0.42) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL2718606 0.91 KDM4E (0.60) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL12191679 0.91 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL12512715 0.91 KDM4E (0.42) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL106226 0.90 KDM4E (0.51) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL18586975 0.88 KDM4E (0.47) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL122651 0.86 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL18713333 0.86 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL19159329 0.86 KDM4E (0.46) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL12964150 0.83 KDM4E (0.43) KDM4EALDH1A1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7268196-B2 Process for producing cycloolefin addition polymer JSR CORPORATION (JP) 2007-09-11 US disclosed
US-7241847-B2 Process for producing cycloolefin addition polymer JSR CORPORATION (JP) 2007-07-10 US disclosed
US-20070123667-A1 PROCESS FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR CORPORATION (JP) 2007-05-31 US disclosed
US-20060217505-A1 Process for producing cycloolefin addition polymer JRS CORPORATION (JP) 2006-09-28 US disclosed
EP-1657259-A1 PROCESS FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR Corporation (JP) 2006-05-17 EP disclosed