Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | DCUN1D2 | Q6PH85 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928413 | 0.94 | DCUN1D1 (0.33) | DCUN1D1DCUN1D2AKT1AKT2LMNA | |
| SCHEMBL4712959 | 0.82 | DCUN1D1 (0.36) | DCUN1D1DCUN1D2 | |
| SCHEMBL3397570 | 0.81 | DCUN1D1 (0.47) | DCUN1D1DCUN1D2AKT1AKT2LMNA | |
| SCHEMBL29499607 | 0.81 | DCUN1D1 (0.47) | DCUN1D1DCUN1D2AKT1AKT2LMNA | |
| SCHEMBL732914 | 0.80 | AKT2 (0.37) | AKT1AKT2LMNA | |
| SCHEMBL29034386 | 0.78 | DCUN1D1 (0.45) | DCUN1D1DCUN1D2AKT1AKT2LMNA | |
| SCHEMBL5251206 | 0.76 | — | — | |
| SCHEMBL4705929 | 0.76 | — | — | |
| Water SCHEMBL7382263 | 0.75 | NR1H2 (0.42) | DCUN1D1LMNA | |
| SCHEMBL618853 | 0.75 | BACE1 (0.39) | DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753746-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005105789-A2 | NOVEL PYRROLE DERIVATIVES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY | ROTTAPHARM S.P.A. (IT) | 2005-11-10 | — | — | WO | disclosed |
| EP-0654027-A1 | PRODRUGS OF IMIDAZOLE CARBOXYLIC ACIDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |