Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 9/20 | 0.68 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.68 |
| ▸ | TTK | P33981 | 5/20 | 0.67 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.61 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.61 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803542 | 0.92 | TTK (0.68) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5388071 | 0.86 | TTK (0.56) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5375624 | 0.86 | TTK (0.56) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5373228 | 0.84 | TTK (0.54) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5381231 | 0.82 | AURKA (0.59) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL2571860 | 0.81 | TTK (1.00) | MAPK1MAPK3TTK | |
| SCHEMBL2582534 | 0.81 | TTK (1.00) | TTK | |
| SCHEMBL2866791 | 0.79 | MAP2K4 (0.69) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5800300 | 0.79 | TTK (0.57) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 | |
| SCHEMBL5799963 | 0.78 | TTK (0.56) | MAPK1MAPK3TTKMAP2K4MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |