Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.56 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.55 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.55 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800300 | 0.92 | TTK (0.57) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5375624 | 0.88 | TTK (0.56) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5377830 | 0.86 | MAPK1 (0.68) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5373228 | 0.82 | TTK (0.54) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5381231 | 0.80 | AURKA (0.59) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5803542 | 0.78 | TTK (0.68) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5800463 | 0.78 | MAP2K4 (0.56) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5377426 | 0.78 | TTK (0.68) | TTKMAPK1MAPK3MAP2K4AURKA | |
| SCHEMBL2866791 | 0.77 | MAP2K4 (0.69) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 | |
| SCHEMBL5799963 | 0.76 | TTK (0.56) | TTKMAPK1MAPK3MAP2K4MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |