Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.63 |
| ▸ | AURKA | O14965 | 9/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.54 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.54 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.54 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.54 |
| ▸ | TTK | P33981 | 4/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785886 | 0.91 | AURKA (0.66) | MAP2K4AURKAMAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL12073910 | 0.89 | TTK (0.65) | MAP2K4AURKAMAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL5379163 | 0.86 | TTK (0.67) | MAP2K4AURKATTKMAPK8AURKB | |
| SCHEMBL5801915 | 0.86 | TTK (0.60) | MAP2K4AURKAMAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL5800458 | 0.86 | MAP2K4 (0.53) | MAP2K4AURKATTKMAPK8MAP2K7 | |
| SCHEMBL5381639 | 0.85 | AAK1 (0.59) | MAP2K4AURKATTKMAPK8MAP2K7 | |
| SCHEMBL7533484 | 0.85 | MAP2K4 (0.59) | MAP2K4AURKAMAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL5399319 | 0.85 | AURKA (0.56) | MAP2K4AURKAMAPKAPK2TTKMAPK8 | |
| SCHEMBL5372815 | 0.85 | MAP2K4 (0.56) | MAP2K4AURKAMAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL14514461 | 0.85 | AURKA (0.54) | MAP2K4AURKAMAPK1TTKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |