Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373489 | 0.88 | MAP2K4 (0.42) | CHEK1TTKMAP3K5MAPK3MAPK1 | |
| SCHEMBL5378425 | 0.84 | MAP2K4 (0.47) | TTKMAPK3MAPK1 | |
| SCHEMBL5372938 | 0.80 | WNT1 (0.44) | — | |
| SCHEMBL5801677 | 0.78 | MAP2K4 (0.54) | TTKMAP3K5MAPK3MAPK1 | |
| SCHEMBL5372266 | 0.78 | MAP2K4 (0.63) | TTKMAP3K5MAPK1 | |
| SCHEMBL8257307 | 0.77 | MAP3K5 (0.61) | MAP3K5MAPK1 | |
| SCHEMBL5386809 | 0.75 | AURKA (0.48) | TTKMAPK3MAPK1 | |
| SCHEMBL5378042 | 0.74 | MAP3K5 (0.59) | CHEK1MAP3K5 | |
| SCHEMBL8443396 | 0.74 | MAP2K4 (0.43) | TTKMAP3K5MAPK3MAPK1 | |
| SCHEMBL5798990 | 0.74 | MAP2K4 (0.61) | TTKMAP3K5MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |