Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378885 | 0.86 | MAPK1 (0.49) | CSNK2A2CSNK2BADORA1ADORA2AMAPK1 | |
| SCHEMBL13057432 | 0.84 | MAPK1 (0.50) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31334063 | 0.82 | ADORA1 (0.46) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31334809 | 0.82 | ADORA1 (0.46) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31335004 | 0.79 | MAPK3 (0.51) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31334715 | 0.79 | MAPK3 (0.51) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31334077 | 0.77 | MAPK1 (0.45) | ADORA1ADORA2AMAPK1CCNB2CCNE2 | |
| SCHEMBL31333299 | 0.76 | ADORA1 (0.53) | CSNK2A2CSNK2BADORA1ADORA2AMAPK1 | |
| SCHEMBL31334419 | 0.76 | ADORA1 (0.53) | CSNK2A2CSNK2BADORA1ADORA2AMAPK1 | |
| SCHEMBL22097892 | 0.76 | CDH1 (0.45) | CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304071-B2 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-04 | — | — | US | disclosed |
| CN-1863780-A | Protein kinase inhibitor and application thereof | VERTEX PHARMA (US) | 2006-11-15 | — | — | CN | disclosed |
| EP-1546117-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-06-03 | — | — | US | disclosed |
| WO-2004016597-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | JAK1, RAF1, PRKCQ | CSNK2A2 246/4885CSNK2B 222/4885ADORA1 3891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.