Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319629 | 0.98 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL132616 | 0.84 | KMT2A (0.70) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL3476753 | 0.82 | KMT2A (0.67) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL99721 | 0.80 | KMT2A (0.53) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL15875975 | 0.79 | KMT2A (0.52) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL4055394 | 0.79 | HPGD (0.53) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL5319449 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL4055923 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT | |
| SCHEMBL135414 | 0.77 | KMT2A (0.48) | KMT2A | |
| SCHEMBL4059332 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828199-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006063732-A1 | THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | claimed |