SCHEMBL5379142

SCHEMBL5379142

CCNC1(C(N)=O)CCN(c2nncc3c(-c4ccc(F)cc4)n(-c4ccccc4Cl)nc23)CC1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 19/20 0.47
CNR2 P34972 3/20 0.45
KCNH2 Q12809 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5382610 0.94 CNR1 (0.41) CNR1CNR2KCNH2
SCHEMBL5373810 0.94 CNR1 (0.52) CNR1CNR2KCNH2
SCHEMBL5368415 0.92 CNR1 (0.40) CNR1CNR2KCNH2
SCHEMBL5372812 0.92 CNR1 (0.42) CNR1CNR2KCNH2
SCHEMBL5372895 0.89 CNR1 (0.41) CNR1CNR2KCNH2
SCHEMBL5375575 0.88 CNR1 (0.45) CNR1CNR2KCNH2
SCHEMBL5391831 0.86 CNR1 (0.46) CNR1CNR2
SCHEMBL5375528 0.86 CNR1 (0.39) CNR1CNR2KCNH2
SCHEMBL5379203 0.84 CNR1 (0.41) CNR1CNR2KCNH2
SCHEMBL5375366 0.84 CNR1 (0.42) CNR1CNR2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7232823-B2 Cannabinoid receptor ligands and uses thereof PFIZER, INC. (US) 2007-06-19 US claimed
US-20040248881-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC 2004-12-09 US claimed
US-20070213334-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF CARPINO PHILIP A 2007-09-13 US disclosed
US-7232823-B2 Cannabinoid receptor ligands and uses thereof PFIZER, INC. (US) 2007-06-19 US disclosed
CN-1805963-A Cannabinoid receptor ligands and uses thereof PFIZER (US) 2006-07-19 CN disclosed
EP-1636233-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF Pfizer Products Inc. (US) 2006-03-22 EP disclosed
WO-2004108728-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2004-12-16 WO disclosed
US-20040248881-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC 2004-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248881-A1 Cannabinoid receptor ligands and uses thereof CNR1, CNR2, GPR18 CNR1 1/4885CNR2 2/4885KCNH2 3162/4885
US-20070213334-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF CNR2, CNR1, GPR18 CNR1 2/4885CNR2 1/4885KCNH2 3027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.