⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242404 | 0.88 | — | — | |
| SCHEMBL2241847 | 0.88 | — | — | |
| SCHEMBL2242655 | 0.85 | CYP2C19 (0.31) | — | |
| SCHEMBL11409928 | 0.81 | — | — | |
| SCHEMBL2959604 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL5379755 | 0.67 | — | — | |
| SCHEMBL28949183 | 0.67 | — | — | |
| SCHEMBL22726575 | 0.67 | — | — | |
| SCHEMBL16941990 | 0.65 | — | — | |
| SCHEMBL808920 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102249949-B | Preparation method of cyclopropyl fenpropathin derivative | QIKAI DALIAN CHEMICAL CO LTD | 2013-12-18 | — | — | CN | claimed |
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |
| US-10287299-B2 | Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity | UCB BIOPHARMA SPRL (BE) | 2019-05-14 | — | — | US | disclosed |
| US-20180134728-A1 | Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity | UCB S.A. (BE) | 2018-05-17 | — | — | US | disclosed |
| EP-3303318-A1 | BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY | UCB Biopharma SPRL (BE) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016198400-A1 | BENZOXAZINONE DERIVATIVES AND ANALOGUES THEREOF AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2016-12-15 | — | — | WO | disclosed |
| CN-102249949-B | Preparation method of cyclopropyl fenpropathin derivative | QIKAI DALIAN CHEMICAL CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-102249949-A | Process for preparation of cyclopropyl methyl cyanide derivatives | QIKAI DALIAN CHEMICAL CO LTD | 2011-11-23 | — | — | CN | disclosed |
| US-7211680-B2 | Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 2007-05-01 | — | — | US | disclosed |
| US-7211680-B2 | Vitamin D derivatives with carbo-or heterocyclic substituents at C-25, a process for their production, intermediate products and their use for producing medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 2007-05-01 | — | — | US | disclosed |
| US-20020049344-A1 | NEW VITAMIN D DERIVATIVES WITH CARBO-OR HETEROCYCLIC SUBSTITUENTS AT C-25, A PROCESS FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS AND THEIR USE FOR PRODUCING MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-25 | — | — | US | disclosed |
| CN-1216978-A | Vitamin D-derivatives having a carbocyclic or heterocyclic substituent at C-25, method for the production thereof, intermediate products and use thereof for producing medicaments | SCHERING AG (DE) | 1999-05-19 | — | — | CN | disclosed |
| EP-0436348-B1 | Pyridyl cyclopropane derivatives with fungicidal activity | ZENECA LTD (GB) | 1996-11-13 | — | — | EP | disclosed |
| US-5126338-A | FUNGICIDES WHICH ARE N-PYRIDYL-CYCLOPROPANE CARBOXAMIDES OR DERIVATIVES THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-06-30 | — | — | US | disclosed |
| EP-0436348-A2 | Pyridyl cyclopropane derivatives with fungicidal activity | ZENECA LIMITED (GB) | 1991-07-10 | — | — | EP | disclosed |
| EP-0182769-B1 | 2,6-SUBSTITUTED PYRIDINE COMPOUNDS | Monsanto Company (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4921530-A | Certain 3,5-pyridine dicarboxylates, their thio analogues having herbicidal activity | MONSANTO COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4835279-A | 2,6-substituted pyridine compounds | MONSANTO COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| US-4797149-A | HERBICIDES | MONSANTO COMPANY (US) | 1989-01-10 | — | — | US | disclosed |
| US-4698093-A | POST, PRE EMERGENTS | MONSANTO COMPANY (US) | 1987-10-06 | — | — | US | disclosed |