Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 5/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069137 | 0.84 | NR3C1 (0.71) | NR3C1NR3C2PGRL3MBTL1LMNA | |
| SCHEMBL4066578 | 0.80 | NR3C1 (0.57) | NR3C1NR3C2PGRCPT2CPT1A | |
| SCHEMBL4077768 | 0.74 | NR3C1 (0.55) | NR3C1NR3C2PGR | |
| SCHEMBL4070557 | 0.73 | NR3C1 (0.56) | NR3C1NR3C2PGRHTR6CAMK2D | |
| SCHEMBL4066170 | 0.72 | NR3C1 (0.70) | NR3C1NR3C2PGRHTR6LMNA | |
| SCHEMBL4068200 | 0.72 | NR3C1 (0.54) | NR3C1NR3C2PGRMAPT | |
| SCHEMBL4074064 | 0.72 | NR3C1 (0.54) | NR3C1NR3C2PGRCAMK2DASH1L | |
| SCHEMBL4069447 | 0.71 | NR3C1 (0.56) | NR3C1NR3C2PGRASH1L | |
| SCHEMBL4067703 | 0.70 | NR3C1 (0.60) | NR3C1NR3C2PGRLMNASMN1; SMN2 | |
| SCHEMBL17997422 | 0.70 | KCNH2 (0.56) | HTR6CPT2CPT1ACPT1BCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836166-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071609-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |