Sugi Predict

Sugi Predict / Compounds / SCHEMBL538048

SCHEMBL538048

SCHEMBL538048

COC(=O)c1sccc1NN

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 1/20 0.63
▸ HPGD P15428 4/20 0.59
▸ SMN1; SMN2 Q16637 2/20 0.59
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ LMNA P02545 3/20 0.56
▸ KDM4E B2RXH2 2/20 0.56
▸ NPSR1 Q6W5P4 2/20 0.56
▸ MAPK10 P53779 2/20 0.56
▸ ALDH1A1 P00352 2/20 0.56
▸ MAPT P10636 2/20 0.56
▸ KMT2A Q03164 3/20 0.55
▸ POLB P06746 2/20 0.55
▸ PKM P14618 1/20 0.55
▸ ATM Q13315 1/20 0.55
▸ MAPK1 P28482 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ MEN1 O00255 2/20 0.54
▸ GAA P10253 1/20 0.54
▸ TSHR P16473 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15846889 0.83 NPC1 (0.65) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL3579523 0.83 NPC1 (0.65) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL995011 0.82 NPC1 (0.69) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL4956852 0.81 NPC1 (0.63) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL1367369 0.80 NPC1 (0.71) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL27884041 0.79 NPC1 (0.59) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL2430838 0.79 NPC1 (0.59) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL2799189 0.79 NPC1 (0.59) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL9410725 0.79 NPC1 (0.59) NPC1HPGDSMN1; SMN2L3MBTL1LMNA
SCHEMBL7933290 0.78 MAPK8 (0.66) NPC1HPGDSMN1; SMN2L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3853219-B1 HERBICIDALLY ACTIVE SUBSTITUTED PHENYLPYRIMIDINE HYDRAZIDES BAYER AG (DE) 2023-07-12 — — EP disclosed
US-20220033363-A1 HERBICIDALLY ACTIVE SUBSTITUTED PHENYLPYRIMIDINE HYDRAZIDES BAYER AKTIENGESELLSCHAFT (DE) 2022-02-03 — — US disclosed
US-20200283398-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2020-09-10 — — US disclosed
WO-2020058062-A1 HERBICIDALLY ACTIVE SUBSTITUTED PHENYLPYRIMIDINE HYDRAZIDES BAYER AKTIENGESELLSCHAFT (DE) 2020-03-26 — — WO disclosed
US-10442777-B2 Use of substituted oxadiazoles for combating phytopathogenic fungi BASF SE (DE) 2019-10-15 — — US disclosed
US-20190016694-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2019-01-17 — — US disclosed
US-20170144980-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2017-05-25 — — US disclosed
US-8598159-B2 Therapeutic pyrazoloquinoline derivatives DART NEUROSCIENCE (CAYMAN) LTD. (KY) 2013-12-03 — — US disclosed
EP-2164328-B1 THERAPEUTIC PYRAZOLOQUINOLINE UREA DERIVATIVES DART NEUROSCIENCE CAYMAN LTD (KY) 2013-08-07 — — EP disclosed
US-8343957-B2 Therapeutic pyrazoloquinoline urea derivatives DART NEUROSCIENCE (CAYMAN) LTD. (KY) 2013-01-01 — — US disclosed
US-20020002152-A1 Hydrazide and alkoxyamide angiogenesis inhibitors ABBOTT LABORATORIES 2002-01-03 — — US disclosed
EP-1157992-A1 Dihydro-2,3-Benzodiazepine derivatives ELI LILLY AND COMPANY (US) 2001-11-28 — — EP disclosed
WO-2001079157-A1 HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2001-10-25 — — WO disclosed
US-5795886-A ANTICONVULSANTS ELI LILLY AND COMPANY (US) 1998-08-18 — — US disclosed
EP-0771198-A4 — — 1997-05-28 — — EP disclosed
EP-0771198-A1 DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES ELI LILLY AND COMPANY (US) 1997-05-07 — — EP disclosed
WO-1996006606-A1 DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES ELI LILLY AND COMPANY (US) 1996-03-07 — — WO disclosed
EP-0182165-B1 THIENYL CONDENSED-PYRAZOLE DERIVATIVES SHIONOGI & CO., LTD. (JP) 1989-08-16 — — EP disclosed
US-4690930-A TRANQUILIZERS, ANTICONVULSANTS SHIONOGI & CO., LTD (JP) 1987-09-01 — — US disclosed
EP-0182165-A1 Thienyl condensed-pyrazole derivatives SHIONOGI & CO., LTD. (JP) 1986-05-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190016694-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI CYP51A1, DPM1, NOX1 NPC1 2259/4885HPGD 650/4885SMN1; SMN2 3626/4885
US-10442777-B2 Use of substituted oxadiazoles for combating phytopathogenic fungi CYP51A1, DPM1, NOX1 NPC1 2259/4885HPGD 650/4885SMN1; SMN2 3626/4885
US-20220033363-A1 HERBICIDALLY ACTIVE SUBSTITUTED PHENYLPYRIMIDINE HYDRAZIDES DDT, CBR3, CAT NPC1 4331/4885HPGD 234/4885SMN1; SMN2 3601/4885
US-20020002152-A1 Hydrazide and alkoxyamide angiogenesis inhibitors METAP2, METAP1, ANPEP NPC1 3808/4885HPGD 889/4885SMN1; SMN2 4547/4885
US-20200283398-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI CYP51A1, DPM1, NOX1 NPC1 2259/4885HPGD 650/4885SMN1; SMN2 3626/4885
US-20170144980-A1 USE OF SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI CYP51A1, DPM1, NOX1 NPC1 2259/4885HPGD 650/4885SMN1; SMN2 3626/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.