Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371161 | 1.00 | F10 (0.34) | F10HDAC8HDAC6 | |
| SCHEMBL5371113 | 0.87 | F10 (0.47) | F10 | |
| SCHEMBL5380004 | 0.87 | F10 (0.47) | F10 | |
| SCHEMBL5381540 | 0.83 | HDAC8 (0.33) | HDAC8HDAC6 | |
| SCHEMBL5384027 | 0.82 | HDAC8 (0.32) | F10HDAC8HDAC6 | |
| SCHEMBL5377448 | 0.81 | HDAC8 (0.40) | HDAC8HDAC6 | |
| SCHEMBL5380049 | 0.79 | F10 (0.39) | F10 | |
| SCHEMBL5386312 | 0.78 | F10 (0.39) | F10 | |
| SCHEMBL5380531 | 0.77 | F10 (0.38) | F10 | |
| SCHEMBL5379823 | 0.77 | F10 (0.38) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235544-B2 | for use in conjunction with thrombolytic agents, thus permitting the use of a lower dose of thrombolytic agent; treatment of acute vascular diseases; may have potential in neurogenerative diseases such as Parkinson's and Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |