Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360850 | 0.87 | AKT1 (0.44) | AKT1TACR3AKT2 | |
| SCHEMBL866493 | 0.87 | AKT1 (0.52) | AKT1TACR3AKT2 | |
| SCHEMBL363205 | 0.81 | AKT1 (0.43) | AKT1TACR3AKT2 | |
| SCHEMBL869068 | 0.81 | AKT1 (0.60) | AKT1AKT2 | |
| SCHEMBL361402 | 0.76 | AKT1 (0.51) | AKT1TACR3AKT2 | |
| SCHEMBL12503412 | 0.75 | AKT1 (0.68) | AKT1AKT2 | |
| SCHEMBL868228 | 0.74 | AKT1 (0.49) | AKT1TACR3AKT2 | |
| SCHEMBL12506640 | 0.74 | AKT1 (0.45) | AKT1TACR3AKT2 | |
| SCHEMBL362980 | 0.72 | AKT1 (0.53) | AKT1TACR3AKT2 | |
| SCHEMBL12506520 | 0.72 | AKT1 (0.47) | AKT1TACR3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |