Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.53 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542294 | 0.78 | PTGER3 (0.41) | AKR1B1AKR1A1PDE7APTGER3LMNA | |
| SCHEMBL7099930 | 0.75 | LMNA (0.51) | AKR1B1AKR1A1LMNAMMP2MMP3 | |
| SCHEMBL542817 | 0.75 | LMNA (0.51) | AKR1B1AKR1A1LMNAMMP2MMP3 | |
| SCHEMBL542398 | 0.75 | LMNA (0.55) | AKR1B1LMNAMMP2 | |
| SCHEMBL25400175 | 0.73 | LMNA (0.50) | AKR1B1AKR1A1HCAR2LMNAMMP2 | |
| SCHEMBL29949390 | 0.73 | LMNA (0.50) | AKR1B1AKR1A1HCAR2LMNAMMP2 | |
| SCHEMBL29949272 | 0.71 | LMNA (0.51) | LMNAMMP2MMP14 | |
| SCHEMBL11001789 | 0.69 | AKR1B1 (1.00) | AKR1B1AKR1A1 | |
| SCHEMBL21940203 | 0.69 | PDE7A (0.50) | AKR1B1AKR1A1PDE7A | |
| SCHEMBL8207892 | 0.69 | TP53 (0.42) | AKR1B1AKR1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160449-B2 | Proline chiral columns with broad chiral selectivity | VANDERBILT UNIVERSITY (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160449-B2 | Proline chiral columns with broad chiral selectivity | VANDERBILT UNIVERSITY (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160449-B2 | Proline chiral columns with broad chiral selectivity | VANDERBILT UNIVERSITY (US) | 2007-01-09 | — | — | US | disclosed |
| US-7141160-B2 | Chiral columns with broad chiral selectivity | V{dot over (a)}nderbilt University (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050092686-A1 | Proline chiral columns with broad chiral selectivity | LI, TINGYU | 2005-05-05 | — | — | US | disclosed |