Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377580 | 0.92 | GSK3B (0.87) | GSK3BCSNK1DMAP4K4PRKACACLK4 | |
| SCHEMBL7395693 | 0.86 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5380569 | 0.86 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5384096 | 0.86 | GSK3B (0.73) | GSK3BMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL5400000 | 0.86 | GSK3B (0.73) | GSK3BMAPK14MAPK13RAF1BRAF | |
| SCHEMBL5381549 | 0.86 | GSK3B (1.00) | GSK3BMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL7397401 | 0.82 | GSK3B (0.68) | GSK3BBRAFCSNK1DMAP4K4PRKACA | |
| SCHEMBL5383544 | 0.82 | GSK3B (0.68) | GSK3BMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL5380418 | 0.81 | GSK3B (0.66) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5381426 | 0.80 | GSK3B (0.78) | GSK3BKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |