Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.68 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377580 | 0.87 | GSK3B (0.87) | GSK3BXDHCDC7DYRK3ROCK2 | |
| SCHEMBL5388178 | 0.85 | GSK3B (0.67) | GSK3BPKN1PKN2MAPK14MAPK13 | |
| SCHEMBL5380875 | 0.82 | GSK3B (0.75) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5384096 | 0.81 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7395693 | 0.81 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5400000 | 0.81 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5380569 | 0.81 | GSK3B (0.73) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5381549 | 0.81 | GSK3B (1.00) | GSK3BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7397401 | 0.78 | GSK3B (0.68) | GSK3BALOX5XDHCDC7DYRK3 | |
| SCHEMBL5383543 | 0.78 | PKN1 (0.53) | GSK3BPKN1PKN2MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |