Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.60 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25961093 | 0.91 | SLC7A5 (0.58) | SLC7A5CYP4F2CYP4A11LOXL2PPARG | |
| SCHEMBL12301533 | 0.89 | SLC7A5 (0.65) | SLC7A5CYP4F2CYP4A11LOXL2KAT6A | |
| SCHEMBL31487557 | 0.88 | CYP4F2 (0.69) | SLC7A5CYP4F2CYP4A11LOXL2PPARA | |
| SCHEMBL7505386 | 0.88 | CYP4F2 (0.69) | SLC7A5CYP4F2CYP4A11LOXL2PPARA | |
| SCHEMBL7504785 | 0.86 | SLC7A5 (0.63) | SLC7A5CYP4F2CYP4A11LOXL2STAT3 | |
| SCHEMBL31487728 | 0.86 | SLC7A5 (0.59) | SLC7A5CYP4F2CYP4A11LOXL2ALDH1A1 | |
| SCHEMBL14415229 | 0.85 | CYP4A11 (0.68) | SLC7A5CYP4F2CYP4A11LOXL2PPARG | |
| SCHEMBL14838275 | 0.85 | SLC7A5 (0.58) | SLC7A5CYP4F2CYP4A11LOXL2ALDH1A1 | |
| SCHEMBL30873957 | 0.85 | SLC7A5 (0.61) | SLC7A5CYP4F2CYP4A11LOXL2PPARG | |
| SCHEMBL3499880 | 0.84 | SLC7A5 (0.63) | SLC7A5CYP4F2CYP4A11LOXL2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | SLC7A5 1489/4885CYP4F2 4104/4885CYP4A11 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.