Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623457 | 0.87 | ADORA2A (0.59) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11017311 | 0.87 | ADORA2A (0.51) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4796596 | 0.84 | PDE1A (0.46) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4626790 | 0.84 | ADORA2A (0.58) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11020666 | 0.84 | ADORA2A (0.42) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9645114 | 0.84 | ADORA2A (0.49) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10535017 | 0.84 | ADORA2A (0.49) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6676076 | 0.84 | HPGD (0.38) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9706596 | 0.84 | ADORA2A (0.41) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9644450 | 0.83 | ADORA2A (0.53) | ADORA2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150184166-A1 | CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-07-02 | — | — | US | claimed |
| EP-2861740-A1 | CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES | University of Iowa Research Foundation (US) | 2015-04-22 | — | — | EP | claimed |
| WO-2013187957-A1 | CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2013-12-19 | — | — | WO | claimed |
| EP-2344126-A1 | METHOD FOR TREATMENT OF COPD AND OTHER PULMONARY DISEASES | Activaero GmbH (DE) | 2011-07-20 | — | — | EP | claimed |
| WO-2010043981-A1 | METHOD FOR TREATMENT OF COPD AND OTHER PULMONARY DISEASES | ACTIVAERO GMBH (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
| EP-1322185-A2 | BEVERAGE COMPOSITIONS COMPRISING ARABINOGALACTAN AND MINERAL SUPPLEMENT | THE PROCTER & GAMBLE COMPANY (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002026053-A2 | BEVERAGE COMPOSITIONS COMPRISING ARABINOGALACTAN AND MINERAL SUPPLEMENT | THE PROCTER & GAMBLE COMPANY (US) | 2002-04-04 | — | — | WO | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |
| EP-0038784-B1 | 3,8-DIALKYLXANTHINES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Aktiebolaget DRACO (SE) | 1984-10-31 | — | — | EP | disclosed |
| EP-0038784-A2 | 3,8-Dialkylxanthines, processes for their preparation and compositions containing them | Aktiebolaget DRACO (SE) | 1981-10-28 | — | — | EP | disclosed |