Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.46 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645631 | 0.89 | ADORA2A (0.40) | PDE1APDE1BPDE1CPDE5AMEN1 | |
| SCHEMBL9646522 | 0.86 | KDM4E (0.44) | PDE1APDE1BPDE1CPDE5AMEN1 | |
| SCHEMBL9645117 | 0.86 | TSHR (0.45) | MEN1KMT2ATSHRBLMALDH1A1 | |
| SCHEMBL4623653 | 0.85 | PDE5A (0.43) | PDE1APDE1BPDE1CPDE5AMEN1 | |
| SCHEMBL538418 | 0.84 | ADORA2A (0.54) | BLMSIRT1SIRT3SIRT5ALDH1A1 | |
| SCHEMBL7007230 | 0.82 | MEN1 (0.50) | PDE1APDE1BPDE1CPDE5AMEN1 | |
| SCHEMBL5646 | 0.82 | PDE2A (0.61) | PDE1APDE1BPDE1CPDE5AMEN1 | |
| SCHEMBL4623457 | 0.82 | ADORA2A (0.59) | BLMSIRT1SIRT3SIRT5HPGD | |
| SCHEMBL3110928 | 0.81 | PNP (0.48) | PDE5AMEN1KMT2ATSHRKDM4E | |
| SCHEMBL19583186 | 0.81 | KDM4E (0.43) | PDE1APDE1BPDE1CPDE5AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008028250-A1 | THERAPEUTIC AGENTS, TARGETS AND DIAGNOSTICS | AUTOGEN RESEARCH PTY LTD (AU) | 2008-03-13 | — | — | WO | disclosed |
| EP-1141020-A4 | DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0935601-A4 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARM CO (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1141020-A2 | DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF | Synaptic Pharmaceutical Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039279-A2 | DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-0935601-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | Du Pont Pharmaceuticals Company (US) | 1999-08-18 | — | — | EP | disclosed |
| EP-0772448-A4 | CYCLIC ANALOGS OF PTH AND PTHrP | BETH ISRAEL HOSPITAL (US) | 1999-05-26 | — | — | EP | disclosed |
| WO-1997035539-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |
| EP-0772448-A1 | CYCLIC ANALOGS OF PTH AND PTHrP | Beth Israel Deaconess Medical Center, Inc. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996040193-A1 | CYCLIC ANALOGS OF PTH AND PTHrP | BETH ISRAEL HOSPITAL ASSOCIATION (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0700438-A1 | OPIOID RECEPTORS: COMPOSITIONS AND METHODS | ARCH DEVELOPMENT CORPORATION (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0668910-A1 | HUMAN NEUROPEPTIDE Y-Y1 RECEPTOR | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 1995-08-30 | — | — | EP | disclosed |
| WO-1995001773-A9 | STIMULATION OF TANNING BY DNA FRAGMENTS | — | 1995-02-16 | — | — | WO | disclosed |
| WO-1994028132-A2 | OPIOID RECEPTORS: COMPOSITIONS AND METHODS | ARCH DEVELOPMENT CORPORATION (US) | 1994-12-08 | — | — | WO | disclosed |
| EP-0668910-A4 | HUMAN NEUROPEPTIDE Y-Y1 RECEPTOR. | GARVAN INST MED RES (AU) | 1994-10-20 | — | — | EP | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |
| EP-0101681-A4 | Antibody to a mediator activity composition and its use in a pharmaceutical composition. | UNIV ROCKEFELLER (US) | 1985-06-06 | — | — | EP | disclosed |
| EP-0101681-A1 | Antibody to a mediator activity composition and its use in a pharmaceutical composition. | UNIV ROCKEFELLER (US) | 1984-03-07 | — | — | EP | disclosed |
| WO-1983000930-A1 | LIPOPROTEIN LIPASE SUPPRESSION BY ENDOTOXIN-INDUCE MEDIATOR (SHOCK ASSAY) | UNIV ROCKEFELLER (US) | 1983-03-17 | — | — | WO | disclosed |