SCHEMBL538441

SCHEMBL538441

Cc1ccc(-c2cccc(C(=Cc3ccccc3)c3ccccc3)c2N)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.43
ESR1 P03372 1/20 0.37
MAPT P10636 3/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
POLB P06746 1/20 0.37
CYP19A1 P11511 2/20 0.36
CYP11B2 P19099 2/20 0.36
CYP1B1 Q16678 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
HPGD P15428 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
ATM Q13315 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MMP9 P14780 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27485319 0.85 TAAR1 (0.40) PTGS2ESR1CYP19A1CYP11B2MEN1
SCHEMBL7655753 0.82 PTGS2 (0.42) PTGS2MAPTNPC1RAB9APOLB
SCHEMBL5047517 0.79 PTGS2 (0.51) PTGS2ESR1MAPTNPC1RAB9A
SCHEMBL27511062 0.78 MAPT (0.38) PTGS2MAPTNPC1RAB9APOLB
SCHEMBL828195 0.76 ESR1 (0.48) PTGS2ESR1CYP19A1CYP11B2ALDH1A1
SCHEMBL828193 0.76 ESR1 (0.48) PTGS2ESR1CYP19A1CYP11B2ALDH1A1
SCHEMBL29222532 0.74 PTGS2 (0.68) PTGS2ESR1MAPTNPC1RAB9A
SCHEMBL5945849 0.74 ESR1 (0.53) PTGS2ESR1CYP19A1CYP11B2ALDH1A1
SCHEMBL128790 0.74 ESR1 (0.43) PTGS2ESR1CYP19A1CYP11B2ALDH1A1
SCHEMBL28140315 0.73 ESR1 (0.40) PTGS2ESR1MAPTPOLBCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
EP-2146251-B1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH CO LTD (JP) 2012-02-08 EP disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
EP-2146251-A1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge Ricoh Company, Ltd. (JP) 2010-01-20 EP disclosed
CN-1224866-C Electronic photographic photo-receptor, image-forming method and instrument, and film cartridge for treatment RICOH KK (JP) 2005-10-26 CN disclosed
CN-1405640-A Electronic photographic photo-receptor, image-forming method and instrument, and film cartridge for treatment RICOH KK (JP) 2003-03-26 CN disclosed