Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.43 |
| ▸ | AKT2 | P31751 | 4/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 2/20 | 0.35 |
| ▸ | SKP1 | P63208 | 2/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167530 | 1.00 | AKT1 (0.43) | AKT1AKT2BRD9CNR1CNR2 | |
| SCHEMBL539038 | 0.90 | AKT1 (0.52) | AKT1AKT2CNR1CNR2 | |
| SCHEMBL868138 | 0.86 | AKT1 (0.41) | AKT1AKT2CNR1CNR2CKS1B | |
| SCHEMBL10167527 | 0.86 | AKT1 (0.44) | AKT1AKT2CNR1CNR2CKS1B | |
| SCHEMBL10167403 | 0.86 | AKT1 (0.41) | AKT1AKT2CNR1CNR2CKS1B | |
| SCHEMBL867901 | 0.86 | AKT1 (0.44) | AKT1AKT2CNR1CNR2CKS1B | |
| SCHEMBL867698 | 0.85 | AKT1 (0.47) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL10167524 | 0.85 | AKT1 (0.47) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL538446 | 0.78 | AKT1 (0.53) | AKT1AKT2 | |
| SCHEMBL10167525 | 0.78 | AKT1 (0.53) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |