Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167524 | 1.00 | AKT1 (0.47) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL867901 | 0.91 | AKT1 (0.44) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL10167527 | 0.91 | AKT1 (0.44) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL867700 | 0.90 | AKT1 (0.57) | AKT1AKT2 | |
| SCHEMBL538478 | 0.85 | AKT1 (0.43) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL10167530 | 0.85 | AKT1 (0.43) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL10167403 | 0.84 | AKT1 (0.41) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL868138 | 0.84 | AKT1 (0.41) | AKT1AKT2CKS1BSKP1SKP2 | |
| SCHEMBL868340 | 0.81 | AKT1 (0.54) | AKT1AKT2 | |
| SCHEMBL538685 | 0.79 | AKT1 (0.55) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077810-A1 | Inhibitors Of AKT Activity | MERCK SHARP & DOHME LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077810-A1 | Inhibitors Of AKT Activity | PIK3CA, PIK3CD, PIK3CB | AKT1 11/4885AKT2 7/4885CKS1B 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.