Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 1.00 |
| ▸ | XDH | P47989 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854866 | 0.83 | SMN1; SMN2 (0.74) | GSK3BXDHSMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL5380514 | 0.81 | GSK3B (0.84) | GSK3BXDHSMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL5386254 | 0.78 | GSK3B (1.00) | GSK3BXDHSMN1; SMN2AKT1CDC7 | |
| SCHEMBL5386996 | 0.77 | GSK3B (0.78) | GSK3BXDHSMN1; SMN2CDC7ROCK2 | |
| SCHEMBL5381263 | 0.77 | GSK3B (0.92) | GSK3BXDHSMN1; SMN2AKT1CDC7 | |
| SCHEMBL5377691 | 0.77 | GSK3B (1.00) | GSK3BXDHSMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL5386570 | 0.77 | GSK3B (0.62) | GSK3BCDC7 | |
| SCHEMBL5381276 | 0.76 | GSK3B (0.90) | GSK3BXDHSMN1; SMN2CDC7ROCK2 | |
| SCHEMBL5400097 | 0.76 | GSK3B (0.90) | GSK3BXDHSMN1; SMN2CDC7ROCK2 | |
| SCHEMBL5376006 | 0.76 | GSK3B (0.90) | GSK3BXDHSMN1; SMN2CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |