Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078851 | 0.77 | MEN1 (0.52) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL5378331 | 0.72 | GRIN1 (0.42) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL5376292 | 0.71 | MAPK14 (0.46) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL5735196 | 0.68 | GMNN (0.43) | ALOX15GRIN1GRIN2BGMNNTP53 | |
| SCHEMBL5806708 | 0.67 | MEN1 (0.55) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL5374691 | 0.67 | GAA (0.47) | GRIN1GRIN2BRPS6KB1GRIN2DGRIN3B | |
| SCHEMBL5374169 | 0.67 | MAPK14 (0.42) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| Hydrochloric Acid SCHEMBL27943768 | 0.66 | MEN1 (0.54) | MAPK14 | |
| SCHEMBL21614171 | 0.65 | MEN1 (0.53) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL5372928 | 0.65 | MAPK14 (0.48) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | claimed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |
| CN-1305464-A | Heterocyclic compounds and methods to treat cardiac failure and other disorders | SCIOS INC (US) | 2001-07-25 | — | — | CN | claimed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | claimed |
| CN-1229351-C | Heterocyclic compounds and methods to treat cardiac failure and other disorders | SCIOS INC (US) | 2005-11-30 | — | — | CN | disclosed |