Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078849 | 0.77 | GAA (0.49) | GAAPLA2G10 | |
| SCHEMBL5376287 | 0.73 | MAPK14 (0.43) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL5374688 | 0.69 | GAA (0.47) | GAA | |
| SCHEMBL5806708 | 0.68 | MEN1 (0.55) | GRIN1GRIN2BCCR3 | |
| SCHEMBL5387256 | 0.68 | ALOX15 (0.42) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL5378327 | 0.67 | CCR3 (0.40) | GMNNTP53CYP3A4ALOX15TSHR | |
| Hydrochloric Acid SCHEMBL27943768 | 0.67 | MEN1 (0.54) | CCR3 | |
| SCHEMBL5732819 | 0.67 | MEN1 (0.46) | CCR3 | |
| SCHEMBL21614171 | 0.66 | MEN1 (0.53) | GRIN1GRIN2BCCR3 | |
| SCHEMBL14439429 | 0.66 | GRIN2B (0.52) | GMNNTP53CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |