Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 12/20 | 0.65 |
| ▸ | PLK1 | P53350 | 10/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034132 | 0.84 | IKBKE (0.74) | IKBKEPLK1NEK2TBK1 | |
| SCHEMBL4035635 | 0.79 | IKBKE (1.00) | IKBKEPLK1TBK1 | |
| SCHEMBL4032804 | 0.70 | IKBKE (0.80) | IKBKEPLK1TBK1 | |
| SCHEMBL14490048 | 0.69 | PLK1 (0.55) | IKBKEPLK1NEK2 | |
| SCHEMBL4032134 | 0.68 | IKBKE (0.79) | IKBKEPLK1TBK1 | |
| SCHEMBL4032682 | 0.68 | IKBKE (0.67) | IKBKEPLK1TBK1 | |
| SCHEMBL5058189 | 0.67 | PLK1 (0.70) | IKBKEPLK1NEK2 | |
| SCHEMBL4033774 | 0.67 | PLK1 (0.68) | IKBKEPLK1TBK1 | |
| SCHEMBL5066012 | 0.67 | PLK1 (0.80) | PLK1NEK2 | |
| SCHEMBL5063355 | 0.67 | PLK1 (0.85) | PLK1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007522142-A | — | — | 2007-08-09 | — | — | JP | claimed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | claimed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | claimed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | claimed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | IKBKE, IKBKB, TBK1 | IKBKE 1/4885PLK1 1088/4885NEK2 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.