Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.41 |
| ▸ | PPARA | Q07869 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381178 | 0.84 | FFAR1 (0.67) | FFAR1PPARGPPARA | |
| Sipoglitazar SCHEMBL5380746 | 0.84 | ALDH1A1 (0.47) | FFAR1FFAR4PPARGPPARA | |
| SCHEMBL5373798 | 0.84 | FFAR1 (0.54) | FFAR1FFAR4PTGER4 | |
| SCHEMBL5377344 | 0.83 | FFAR1 (0.42) | FFAR1FFAR4 | |
| SCHEMBL5382761 | 0.81 | FFAR1 (0.43) | FFAR1FFAR4PTGER4 | |
| SCHEMBL5385574 | 0.81 | FFAR1 (0.45) | FFAR1FFAR4PTGER4 | |
| SCHEMBL5372359 | 0.81 | FFAR1 (0.47) | FFAR1FFAR4PPARDPPARGPPARA | |
| SCHEMBL5380635 | 0.80 | FFAR1 (0.46) | FFAR1FFAR4PTGER4 | |
| SCHEMBL5387526 | 0.80 | FFAR1 (0.65) | FFAR1FFAR4PPARGPPARA | |
| SCHEMBL5372527 | 0.80 | FFAR1 (0.47) | FFAR1FFAR4PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |