Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.36 |
| ▸ | ACP1 | P24666 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753133 | 0.87 | PDE4B (0.39) | PDE4BADORA1MAPTADORA2AADORA2B | |
| SCHEMBL4054075 | 0.80 | ACP1 (0.50) | PDE4BACP1ADORA1MAPTADORA2A | |
| SCHEMBL4051327 | 0.77 | KCNJ6 (0.46) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4061317 | 0.77 | ABCG2 (0.54) | PDE4BACP1ABCB1ABCG2ADORA1 | |
| SCHEMBL4053907 | 0.77 | MEN1 (0.40) | PDE4BADORA1MAPTADORA2A | |
| SCHEMBL4051316 | 0.76 | MEN1 (0.41) | PDE4BADORA1MAPTADORA2A | |
| SCHEMBL4052347 | 0.75 | PDE4B (0.44) | PDE4BADORA1MAPTADORA2AADORA2B | |
| SCHEMBL4051810 | 0.70 | MAPT (0.48) | PDE4BACP1MAPT | |
| SCHEMBL4055062 | 0.69 | ABCG2 (0.41) | PDE4BABCG2ADORA1MAPTADORA2A | |
| SCHEMBL4058677 | 0.69 | GSK3B (0.42) | PDE4BACP1ABCB1ABCG2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510689-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | claimed |