Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051327 | 0.89 | KCNJ6 (0.46) | PDE4BKCNJ6KCNJ5KCNJ3ADORA1 | |
| SCHEMBL4053907 | 0.89 | MEN1 (0.40) | PDE4BKCNJ6KCNJ5KCNJ3MAPT | |
| SCHEMBL5397108 | 0.87 | PDE4B (0.36) | PDE4BMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL4054075 | 0.80 | ACP1 (0.50) | PDE4BMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL4052347 | 0.80 | PDE4B (0.44) | PDE4BMAPTRAB9AADORA1ADORA2A | |
| SCHEMBL4051316 | 0.80 | MEN1 (0.41) | PDE4BMAPTRAB9AADORA1ADORA2A | |
| SCHEMBL4051810 | 0.79 | MAPT (0.48) | PDE4BMAPTKMT2A | |
| SCHEMBL4055345 | 0.77 | GAA (0.47) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL4057455 | 0.77 | ABCG2 (0.52) | PDE4BMAPTADORA1ADORA2AADORA2B | |
| SCHEMBL4057070 | 0.75 | TP53 (0.47) | PDE4BMAPTADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | disclosed |